Technology Process of EtO-Thiazole-D-Phe-Val-NHBoc
There total 3 articles about EtO-Thiazole-D-Phe-Val-NHBoc which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jo3017499
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / 1,2-dimethoxyethane / 0.25 h / 0 °C / Inert atmosphere
1.2: 3 h / 0 °C / Inert atmosphere
1.3: 20 °C / Inert atmosphere
2.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
pyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jo3017499
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/jo3017499
