benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate

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Chemical Name:benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate
CAS No.:1394838-22-2
Molecular Formula:C₂₅H₂₂F₂N₄O₂
Molecular Weight:448.472
Hs Code.:

Synonyms:benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate

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Chemical Property of benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate

There total 6 articles about benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394838-03-9
5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1394838-22-2
benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate

Guidance literature:: 5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid; With N,N-diethyl-N-isopropylamine; diphenylphosphoranyl azide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

benzyl alcohol; In tetrahydrofuran; at 65 ℃; for 72h;

Reference yield:

: 885276-93-7
ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate

: 1394838-22-2
benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 48 h / 50 °C

2.2: 20 °C / pH 6

3.1: N,N-diethyl-N-isopropylamine; diphenylphosphoranyl azide / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 72 h / 65 °C

With N,N-diethyl-N-isopropylamine; diphenylphosphoranyl azide; water; caesium carbonate; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 1364890-03-8
(2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidine

: 1394838-22-2
benzyl (5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 48 h / 50 °C

2.2: 20 °C / pH 6

3.1: N,N-diethyl-N-isopropylamine; diphenylphosphoranyl azide / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 72 h / 65 °C

With N,N-diethyl-N-isopropylamine; diphenylphosphoranyl azide; water; caesium carbonate; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol;