3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid

Base Information

Chemical Name:3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid
CAS No.:936111-25-0
Molecular Formula:C₄₅H₄₈F₂O₇Si
Molecular Weight:766.954
Hs Code.:

Synonyms:3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid

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Chemical Property of 3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid

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Technology Process of 3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid

There total 6 articles about 3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 950684-10-3
methyl 3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonate

: 936111-25-0
3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 1h;
DOI:10.1021/ol070169i

Reference yield:

: 1014698-44-2
ethyl 2-(2,3,4-tri-O-benzyl-6-O-(tert-butyldiphenylsilyl)-α-D-mannopyranosyl)-2,2-difluoroacetate

: 936111-25-0
3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1021/jo702466h

Reference yield:

: 936111-59-0
ethyl (3S,4R,5S,6R)-3-acetoxy-4,5,6-tris(benzyloxy)-2,2-difluorooct-7-enoate

: 936111-25-0
3,7-anhydro-4,5,6-tri-O-benzyl-8-O-t-butyldiphenylsilyl-2,2-difluoro-D-glycero-D-talo-octosonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 83 percent / sodium methylate / methanol / 1 h / 20 °C

2.1: 74 percent Turnov_. / m-CPBA; NaH₂PO₄ / CH₂Cl₂; H₂O / 26 h / 20 °C

3.1: sodium methylate / methanol / 23 h / 20 °C

3.2: 52 percent / methanol / toluene / 0.5 h / 0 °C

4.1: 59 percent / imidazole / dimethylformamide / 2.5 h / 50 °C

5.1: 100 percent / sodium hydroxide / H₂O; ethanol / 1 h

With 1H-imidazole; sodium hydroxide; sodium dihydrogenphosphate; sodium methylate; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol070169i