1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Chemical Name:1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea
CAS No.:1187212-61-8
Molecular Formula:C₃₁H₃₁FN₅O₄PS
Molecular Weight:619.656
Hs Code.:

Synonyms:1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Chemical Property of 1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Technology Process of 1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

There total 8 articles about 1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1187213-92-8
tert-butyl (6-(7-(4-(3-(3-(dimethylphosphoryl)phenyl)ureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate

: 1187212-61-8
1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: tert-butyl (6-(7-(4-(3-(3-(dimethylphosphoryl)phenyl)ureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 645-00-1
m-iodonitrobenzene

: 1187212-61-8
1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3.17 h / 20 - 90 °C / Inert atmosphere

2.1: iron; ammonium chloride / methanol; water / 0.5 h / Inert atmosphere; Reflux

3.1: tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

3.2: 16 h / -20 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

With iron; ammonium chloride; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 26786-59-4
dimethyl(m-nitrophenyl)phosphine oxide

: 1187212-61-8
1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; ammonium chloride / methanol; water / 0.5 h / Inert atmosphere; Reflux

2.1: tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

2.2: 16 h / -20 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

With iron; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;