Technology Process of C19H24FN3O7S
There total 8 articles about C19H24FN3O7S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H25FN2O5S;
With
sulfuric acid; nitric acid;
at -10 ℃;
for 2h;
di-tert-butyl dicarbonate;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 25 ℃;
Resolution of racemate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; dmap / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 16 h / 30 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 1 h / -78 °C
3.1: boron tribromide / dichloromethane / -78 - 25 °C
3.2: 4 h / 25 °C
4.1: nitric acid; sulfuric acid / 2 h / -10 °C
4.2: 25 °C
4.3: Chiral PAK AD column / Resolution of racemate
With
dmap; n-butyllithium; sulfuric acid; nitric acid; boron tribromide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 1 h / -78 °C
2.1: boron tribromide / dichloromethane / -78 - 25 °C
2.2: 4 h / 25 °C
3.1: nitric acid; sulfuric acid / 2 h / -10 °C
3.2: 25 °C
3.3: Chiral PAK AD column / Resolution of racemate
With
n-butyllithium; sulfuric acid; nitric acid; boron tribromide;
In
tetrahydrofuran; hexane; dichloromethane;
