(R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole

Base Information

Chemical Name:(R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole
CAS No.:1286255-50-2
Molecular Formula:C₁₇H₁₄ClN₃O₅
Molecular Weight:375.768
Hs Code.:

Synonyms:(R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole

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Technology Process of (R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole

There total 2 articles about (R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1286255-61-5
4-methyl-3,5-dinitro-N-(2-phenylallyl)benzamide

: 1286255-50-2
(R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole

Guidance literature:: With 1,3-dichloro-5,5-diphenylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine; In trifluoroethanol; at -30 ℃; for 2h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201006910

Reference yield:

: 6633-28-9
3,5-dinitro-4-methylbenzoyl chloride

: 28144-67-4
2-phenylallylamine

: 1286255-50-2
(R)-5-(chloromethyl)-2-(4-methyl-3,5-dinitrophenyl)-5-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

2: 1,3-dichloro-5,5-diphenylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine / trifluoroethanol / 2 h / -30 °C

With dmap; 1,3-dichloro-5,5-diphenylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; In trifluoroethanol; dichloromethane;
DOI:10.1002/anie.201006910