4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

Base Information

Chemical Name:4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide
CAS No.:1202041-89-1
Molecular Formula:C₂₀H₂₀Cl₂N₄O₃S
Molecular Weight:467.376
Hs Code.:

Synonyms:4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

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Chemical Property of 4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

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Technology Process of 4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

There total 7 articles about 4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1174303-50-4
4-cyano-3-(2,4-dichlorophenyl)-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1202041-89-1
4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

Guidance literature:: at 160 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1174304-57-4
4-cyano-3-iodo-5-(methylsulfonyl)thiophene-2-carboxamide

: 1202041-89-1
4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; ISOPROPYLAMIDE / 3 h / 150 °C / Inert atmosphere; Microwave irradiation

2: 60 °C

3: 1 h / 160 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; ISOPROPYLAMIDE;

Reference yield:

: 1174304-56-3
4-cyano-3-iodo-5-(methylsulfanyl)thiophene-2-carboxamide

: 1202041-89-1
4-cyano-3-(2,4-dichlorophenyl)-N-[(1E)-(dimethylamino)methylene]-5-[2-(hydroxymethyl)morpholin-4-yl]thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide / 20 °C

2: potassium phosphate / bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; ISOPROPYLAMIDE / 3 h / 150 °C / Inert atmosphere; Microwave irradiation

3: 60 °C

4: 1 h / 160 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; 3-chloro-benzenecarboperoxoic acid; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;