2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole

Base Information

• Chemical Name: 2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole
• CAS No.: 1339152-42-9
• Molecular Formula: C₂₁H₂₂N₂O₄S₂
• Molecular Weight: 430.549

Synonyms:2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole

Chemical Property of 2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole

There total 2 articles about 2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

p-methoxyl benzaldoxime (3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9) + 2-(2-(p-methylphenyl)ethenesulfonylmethyl)-4,5-dihydrothiazole (1339152-91-8) → 2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole (1339152-42-9)

Guidance literature:

With chloroamine-T; In methanol; Reflux;

DOI:10.1016/j.ejmech.2011.08.010

Reference yield:

methyl E-4-methylstyrylsulfonyl acetate (170884-94-3) → 2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole (1339152-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: samarium(III) chloride; n-butyllithium / toluene / 0.33 h / 0 °C

1.2: Reflux

2.1: chloroamine-T / methanol / Reflux

With n-butyllithium; samarium(III) chloride; chloroamine-T; In methanol; toluene;

DOI:10.1016/j.ejmech.2011.08.010

Reference yield: 65.0%

2-(4,5-dihydro-5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole (1339152-42-9) → 2-(5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole (1339152-77-0)

Guidance literature:

With chloranil; In 5,5-dimethyl-1,3-cyclohexadiene; Reflux;

DOI:10.1016/j.ejmech.2011.08.010

upstream raw materials:

p-methoxyl benzaldoxime

2-(2-(p-methylphenyl)ethenesulfonylmethyl)-4,5-dihydrothiazole

methyl E-4-methylstyrylsulfonyl acetate

Downstream raw materials:

2-(5-(p-methylphenyl)-3-(p-methoxyphenyl)isoxazol-4-ylsulfonylmethyl)-4,5-dihydrothiazole

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