{3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid

Base Information

Chemical Name:{3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid
CAS No.:1352005-73-2
Molecular Formula:C₂₉H₂₄N₄O₃
Molecular Weight:476.535
Hs Code.:

Synonyms:{3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid

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Chemical Property of {3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid

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Technology Process of {3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid

There total 10 articles about {3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: [3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid

: 1352005-48-1
6-(3-bromophenyl)-2-ethyl-4-(isoquinolin-4-ylamino) pyridazin-3(2H)-one

: 1352005-73-2
{3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 140 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1532-97-4
4-bromoisoquinoline

: 1352005-73-2
{3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 140 °C / Microwave irradiation

With potassium tert-butylate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; toluene;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352005-73-2
{3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / ethanol; pentane; tetrahydrofuran; mineral oil / Cooling with ice

1.2: 20 - 40 °C / Reflux

1.3: pH 1 - 2

2.1: ethanol; sodium / 0.25 h / -5 - 0 °C

2.2: 0 - 20 °C

3.1: hydrazine hydrate / ethanol / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h

4.2: 20 - 30 °C

5.1: hydrogen / ethanol; tetrahydrofuran / 724.03 Torr

6.1: water; hydrogen bromide / 1.25 h / 130 °C

7.1: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 140 °C / Microwave irradiation

With ethanol; potassium tert-butylate; water; hydrogen bromide; hydrogen; sodium; sodium hydride; potassium carbonate; hydrazine hydrate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil; pentane;