Technology Process of 6-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-5-methyl-[3-2H]-pyrazin-2-amine
There total 6 articles about 6-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-5-methyl-[3-2H]-pyrazin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
[D]-sodium hydroxide; palladium 10% on activated carbon; deuterium;
In
tetrahydrofuran; d(4)-methanol;
at 20 ℃;
for 2.5h;
under 258.581 Torr;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: caesium carbonate / dimethyl sulfoxide / 16 h / 125 °C
2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 85 °C
3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water; ethanol / 16.25 h / 140 °C / Sealed tube; Inert atmosphere
4: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.75 h / 60 °C
5: [D]-sodium hydroxide; deuterium; palladium 10% on activated carbon / d(4)-methanol; tetrahydrofuran / 2.5 h / 20 °C / 258.58 Torr
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); [D]-sodium hydroxide; palladium 10% on activated carbon; potassium acetate; sodium carbonate; caesium carbonate; deuterium;
In
tetrahydrofuran; 1,4-dioxane; ethanol; d(4)-methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 85 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water; ethanol / 16.25 h / 140 °C / Sealed tube; Inert atmosphere
3: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.75 h / 60 °C
4: [D]-sodium hydroxide; deuterium; palladium 10% on activated carbon / d(4)-methanol; tetrahydrofuran / 2.5 h / 20 °C / 258.58 Torr
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); [D]-sodium hydroxide; palladium 10% on activated carbon; potassium acetate; sodium carbonate; deuterium;
In
tetrahydrofuran; 1,4-dioxane; ethanol; d(4)-methanol; water; N,N-dimethyl-formamide;
![3-bromo-6-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-5-methylpyrazin-2-amine](/Databaselist/images/loading.webp)
