(3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Base Information

Chemical Name:(3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride
CAS No.:1373491-56-5
Molecular Formula:C₁₆H₁₈ClNO₄S*ClH
Molecular Weight:392.303
Hs Code.:

Synonyms:(3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Suppliers and Price of (3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

There total 8 articles about (3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373492-34-2
3-tert-butoxycarbonylmethylene-5-(mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester

: 1373491-56-5
(3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Guidance literature:: 3-tert-butoxycarbonylmethylene-5-(mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; Inert atmosphere;

Reference yield:

: allyl-(1-hydroxyallyl)carbamic acid tert-butyl ester

: 1373491-56-5
(3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 1 h / Inert atmosphere

3.1: dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

5.1: triethylamine; hydrogen sulfide / methanol / 1.25 h / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

7.2: Inert atmosphere

7.3: Inert atmosphere

With hydrogen sulfide; sodium hydride; potassium carbonate; triethylamine; pyridinium chlorochromate; trifluoroacetic acid; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 120568-74-3
N-allyl-N-(2-hydroxy-3-butenyl)amine

: 1373491-56-5
(3-carboxymethylene-5-mercaptopiperidin-1-yl)-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C / Cooling in water bath

2.1: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 1 h / Inert atmosphere

4.1: dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

6.1: triethylamine; hydrogen sulfide / methanol / 1.25 h / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

8.2: Inert atmosphere

8.3: Inert atmosphere

With hydrogen sulfide; sodium hydride; potassium carbonate; triethylamine; pyridinium chlorochromate; trifluoroacetic acid; sodium hydroxide; Grubbs catalyst first generation; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;