(S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Base Information

Chemical Name:(S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester
CAS No.:881902-46-1
Molecular Formula:C₄₀H₅₉N₅O₉
Molecular Weight:753.937
Hs Code.:

(S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Synonyms:(S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

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Chemical Property of (S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of (S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

There total 15 articles about (S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: (S)-(2-{(S)-3-[3-((2S,3S)-3-Cyclohexyl-2-hydroxy-3-isobutoxycarbonylamino-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-hydroxy-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

: 881902-46-1
(S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Guidance literature:: With Dess-Martin periodane; In dichloromethane;
DOI:10.1016/j.bmcl.2005.12.013

Reference yield:

: 882004-10-6
(S)-tert-butyl 3-cyclopropyl-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

: 881902-46-1
(S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 100 percent / HCl / dioxane

2: 47 percent / Et₃N / CH₂Cl₂

3: LAH / tetrahydrofuran / -30 °C

4: CH₂Cl₂

5: 100 percent / HCl / dioxane

6: 83 percent / DIPEA / CH₂Cl₂

7: 70 percent / Et₂O*BF₃

8: 100 percent / aq. LiOH / tetrahydrofuran

9: 95 percent / HATU; DIPEA / dimethylformamide / -20 °C

10: TFA / CH₂Cl₂

11: 73 percent / Dess-Martin periodinane / CH₂Cl₂

With hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 4: Passerini reaction / 11: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2005.12.013

Reference yield:

: 2-amino-3-cyclopropyl-N-methoxy-N-methyl-propionamide; hydrochloride

: 881902-46-1
(S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 47 percent / Et₃N / CH₂Cl₂

2: LAH / tetrahydrofuran / -30 °C

3: CH₂Cl₂

4: 100 percent / HCl / dioxane

5: 83 percent / DIPEA / CH₂Cl₂

6: 70 percent / Et₂O*BF₃

7: 100 percent / aq. LiOH / tetrahydrofuran

8: 95 percent / HATU; DIPEA / dimethylformamide / -20 °C

9: TFA / CH₂Cl₂

10: 73 percent / Dess-Martin periodinane / CH₂Cl₂

With hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 3: Passerini reaction / 10: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2005.12.013