Technology Process of Cbz-GlyAib8PheNH2
There total 7 articles about Cbz-GlyAib8PheNH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Cbz-GlyAib8OH;
With
acetic anhydride;
at 120 ℃;
for 1.5h;
Inert atmosphere;
L-Phenylalanine amide;
In
acetonitrile;
for 48h;
Inert atmosphere;
Reflux;
DOI:10.1021/ja100662d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: palladium on activated charcoal; hydrogen / ethanol
2.1: acetic anhydride / 2 h / 120 °C
2.2: Reflux
3.1: palladium on activated charcoal; hydrogen / ethanol
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h
5.1: trifluoroacetic acid / dichloromethane
6.1: acetic anhydride / 2 h / 120 °C
6.2: Reflux
With
palladium on activated charcoal; hydrogen; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
ethanol; dichloromethane;
DOI:10.1002/bip.21535
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium on activated charcoal; hydrogen / ethanol
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h
3.1: trifluoroacetic acid / dichloromethane
4.1: acetic anhydride / 2 h / 120 °C
4.2: Reflux
With
palladium on activated charcoal; hydrogen; acetic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
ethanol; dichloromethane;
DOI:10.1002/bip.21535
