(8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid

Base Information

Chemical Name:(8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid
CAS No.:1355681-25-2
Molecular Formula:C₂₂H₃₀O₈
Molecular Weight:422.475
Hs Code.:

Synonyms:(8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid

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Chemical Property of (8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid

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Technology Process of (8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid

There total 7 articles about (8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₆O₁₀

: 1355681-25-2
(8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; at 67 ℃; for 2h;

Reference yield:

: C₂₃H₃₂O₈

: 1355681-25-2
(8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; at 67 ℃; for 2h;
DOI:10.1021/ja210202y

Reference yield:

: 83405-98-5
4-(tert-butyl-dimethylsilanyloxy)-benzoic acid

: 1355681-25-2
(8R)-(3'R-hydroxy-5'R-(4-hydroxybenzoyloxy)-6'S-methyl-(2H)-tetrahydropyran-2'-yloxy)non-(2E)-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h

2: water; caesium carbonate / N,N-dimethyl-formamide / 3.5 h

3: water; lithium hydroxide / tetrahydrofuran; 1,4-dioxane / 2 h / 67 °C

With dmap; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja210202y