N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1321619-05-9
Molecular Formula:C₃₀H₁₇F₃N₄O₄
Molecular Weight:554.485
Hs Code.:

Synonyms:N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 4 articles about N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.2%

: 868171-67-9
1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

: 1336879-46-9
C₁₈H₁₁F₂N₃O₂

: 1321619-05-9
N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.05.038

Reference yield:

: 1321618-95-4
C₁₂H₇FN₂O₂

: 1321619-05-9
N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 0.5 h / 100 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.038

Reference yield:

: 1-fluoro-4-(2-chloro-2-nitroethenyl)benzene

: 1321619-05-9
N-(3-fluoro-4-(5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 120 °C / Inert atmosphere

2: trichlorophosphate / 0.5 h / 100 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.038