3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one

Base Information

Chemical Name:3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one
CAS No.:19564-05-7
Molecular Formula:C₁₆H₁₃ClN₂O
Molecular Weight:284.745
Hs Code.:
DSSTox Substance ID:DTXSID101247727

Synonyms:TimTec1_001397;Oprea1_032261;DTXSID101247727;HMS1537P11;STK385264;AKOS000590640;3-(2-Chlorophenyl)-2-ethyl-4(3H)-quinazolinone;3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one;SR-01000323635;SR-01000323635-1;BRD-K81848189-001-01-0;19564-05-7

Suppliers and Price of 3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:284.0716407
Heavy Atom Count:20
Complexity:409

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3Cl

Technology Process of 3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one

There total 2 articles about 3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 95-51-2
o-chloroaniline

: 19165-26-5
2-(propionylamino)benzoic acid

: 19564-05-7
3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one

Guidance literature:: With phosphorus trichloride; In toluene; at 20 - 130 ℃; for 7.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0037-1610110

Reference yield:

: 19564-05-7
3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one

Guidance literature:: Einw. von POCl3 auf N-Propionyl-anthranilsaeure u. /BRN= 606077/, 80-100grad;

Reference yield:

: 106-95-6
allyl bromide

: 19564-05-7
3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one

: (P,S) 3-(2-chlorophenyl)-2-(pent-4-en-2-yl)quinazolin-4(3H)-one

: (P,R) 3-(2-chlorophenyl)-2-(pent-4-en-2-yl)quinazolin-4(3H)-one

Guidance literature:: 3-(2-chlorophenyl)-2-ethylquinazolin-4(3H)-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 0.5h;

allyl bromide; In tetrahydrofuran; at -20 ℃; for 0.5h; diastereoselective reaction;
DOI:10.1055/s-0037-1610110