3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

Base Information

Chemical Name:3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃
CAS No.:219568-92-0
Molecular Formula:C₃₇H₅₀N₆O₈Si₂
Molecular Weight:765.987
Hs Code.:

3',5'-O-TPDS-N<sup>2</sup>-acetyl-O<sup>6</sup>-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H<sub>3</sub>

Synonyms:3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

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Chemical Property of 3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

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Technology Process of 3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

There total 4 articles about 3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 219568-91-9
N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

: 219568-92-0
3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

Guidance literature:: With pyridine; for 2h;
DOI:10.1016/S0040-4020(98)00905-3

Reference yield:

: 112233-74-6
N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

: 219568-92-0
3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) bis(trimethylsilyl)acetamide, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) 1,2-dichloroethane, 83 deg C, 6 h, 2.) toluene, 1,2-dichloroethane, 70 deg C, 6 h and room temperature, overnight

2: 79 percent / NaOH / pyridine; ethanol; H₂O / 0.2 h / 0 °C

3: 80 percent / Py / 2 h

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; bis-(trimethylsilyl)acetamide; In pyridine; ethanol; water;
DOI:10.1016/S0040-4020(98)00905-3

Reference yield:

: 1-O-methyl-2,3,5-tri-O-(4-toluoyl)-α/β-D-ribofuranose-2,3,5(R/S)-2H3

: 219568-92-0
3',5'-O-TPDS-N²-acetyl-O⁶-diphenylcarbamoylguanosine-2',3',5'(R/S)-2H₃

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄, acetic anhydride / CH₂Cl₂ / 0.2 h / 0 °C

2: 1.) bis(trimethylsilyl)acetamide, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) 1,2-dichloroethane, 83 deg C, 6 h, 2.) toluene, 1,2-dichloroethane, 70 deg C, 6 h and room temperature, overnight

3: 79 percent / NaOH / pyridine; ethanol; H₂O / 0.2 h / 0 °C

4: 80 percent / Py / 2 h

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; acetic anhydride; bis-(trimethylsilyl)acetamide; In pyridine; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4020(98)00905-3