5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

Base Information

Chemical Name:5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole
CAS No.:231605-75-7
Molecular Formula:C₃₂H₃₉N₃O₁₁
Molecular Weight:641.675
Hs Code.:

Synonyms:5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

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Chemical Property of 5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

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Technology Process of 5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

There total 9 articles about 5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 231605-74-6
5-benzyloxycarbonylamino-5'-formyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

: 231605-75-7
5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

Guidance literature:: With sodium tetrahydroborate; ammonium chloride; In methanol; dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(99)00239-2

Reference yield:

: 50622-64-5
benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate

: 231605-75-7
5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / H₂, Et₃N / Pd-C / tetrahydrofuran / 8 h / Ambient temperature

2: 86 percent / DPPA, Et₃N / tetrahydrofuran / Ambient temperature

3: SO₂Cl₂ / CH₂Cl₂ / 0.75 h / Ambient temperature

4: CaCO₃ / CH₂Cl₂ / 120 h / Ambient temperature

5: 92 percent / benzene / 1 h / Heating

6: 97 percent / NaBH₄, NH₄Cl / CH₂Cl₂; methanol / 0 - 20 °C

With sodium tetrahydroborate; sulfuryl dichloride; diphenyl-phosphinic acid; hydrogen; ammonium chloride; triethylamine; calcium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4020(99)00239-2

Reference yield:

: 71015-84-4
benzyl 5'-formyl-4,3'-di(2-methoxycarbonylethyl)-3,4'-bismethoxy-carbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate

: 231605-75-7
5-benzyloxycarbonylamino-5'-hydroxymethyl-3',4-di-(2-methoxycarbonylethyl)-3,4'-dimethoxycarbonylmethyl-2,2'-methylenedipyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / H₂, Et₃N / Pd-C / tetrahydrofuran / Ambient temperature

2: 71 percent / DPPA, Et₃N / tetrahydrofuran / Ambient temperature

3: 92 percent / benzene / 1 h / Heating

4: 97 percent / NaBH₄, NH₄Cl / CH₂Cl₂; methanol / 0 - 20 °C

With sodium tetrahydroborate; diphenyl-phosphinic acid; hydrogen; ammonium chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4020(99)00239-2