Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information

Chemical Name:Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:1225210-42-3
Molecular Formula:C₄₀H₃₃ClN₂O₃S
Molecular Weight:657.233
Hs Code.:

Synonyms:Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Property of Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Technology Process of Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 1 articles about Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 79349-53-4
(6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxyli acid diphenylmethyl ester hydrochloride

: 1225210-42-3
Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield: 89.0%

: 1225210-42-3
Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

: 1225210-43-4
Benzhydryl (5R,6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1h; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.ejmech.2018.06.014

Reference yield:

: 1225210-42-3
Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

: 1338706-11-8
(S)-(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone

: C₇₀H₆₆ClN₄O₈S⁽¹⁺⁾*I^(1-)

Guidance literature:: Benzhydryl (6R,7R)-3-(chloromethyl)-8-oxo-7-(tritylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; (S)-(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone; With sodium iodide; In N,N-dimethyl acetamide; at 20 ℃; for 3h;

With acetyl chloride; potassium iodide; In N,N-dimethyl-formamide; for 2h; Cooling with ice;