ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate

Base Information

Chemical Name:ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate
CAS No.:944544-67-6
Molecular Formula:C₂₃H₃₅N₃O₇
Molecular Weight:465.547
Hs Code.:

Synonyms:ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate

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Chemical Property of ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate

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Technology Process of ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate

There total 1 articles about ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

: 72648-80-7
ethyl 2-[2-(tert-butoxycarbonylamino)ethyl-[3-[[4-(4,5-difluoro-2-methylsulfanyl-phenyl)phenoxy]methyl]benzoyl]amino]acetate

: 944544-67-6
ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1016/j.tet.2007.03.109

Reference yield: 88.0%

: 944544-67-6
ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate

: 403731-09-9
N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycine

Guidance literature:: With sodium hydroxide; In methanol; for 3h;
DOI:10.1016/j.tet.2007.03.109

Reference yield:

: 944544-67-6
ethyl N-(4-(benzyloxycarbonylamino)butanoyl)-N-(2-((tert-butoxy)carbonylamino)ethyl)glycinate

: N-(2-((tert-butoxy)carbonylamino)ethyl)-N-(4-(3-(4'-dimethylaminophenylazo)benzoylamino)butanoyl)-glycine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / aq. NaOH / methanol / 3 h

2: 83 percent / H₂ / Pd/C / ethanol / 8 h / 20 °C

3: 91 percent / triethylamine / dimethylformamide / 15 h / 20 °C

With sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.109