Piperidine, 3-cyclopentyl- (9CI)

Base Information

• Chemical Name: Piperidine, 3-cyclopentyl- (9CI)
• CAS No.: 794533-53-2
• Molecular Formula: C₁₀H₁₉N
• Molecular Weight: 153.268
• Mol file: 794533-53-2.mol

Synonyms:3-Cyclopentylpiperidine

Chemical Property of Piperidine, 3-cyclopentyl- (9CI)

Chemical Property:

• Boiling Point: 94 - 96 °C (7.50075 mmHg)
• PSA: 12.03000
• LogP: 2.50500

Purity/Quality:

99% ^*data from raw suppliers

3-Cyclopentylpiperidine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidine, 3-cyclopentyl- (9CI)

There total 3 articles about Piperidine, 3-cyclopentyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(2-bromopyridin-3-yl)cyclopentanol (780801-12-9) → 3-cyclopentylpiperidine (794533-53-2)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 85 ℃; for 64h; under 30003 Torr; Autoclave;

DOI:10.1055/s-0034-1379502

Reference yield: 84.0%

3-cyclopentylpyridine (79134-68-2) → 3-cyclopentylpiperidine (794533-53-2)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; water; for 18h; under 2585.81 Torr;

Reference yield:

2-bromo-pyridine (109-04-6) + cyclopentanone (120-92-3) → 3-cyclopentylpiperidine (794533-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.83 h / -78 °C / Inert atmosphere

1.2: 1.33 h / -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol; water / 64 h / 85 °C / 30003 Torr / Autoclave

With hydrogenchloride; n-butyllithium; palladium 10% on activated carbon; hydrogen; diisopropylamine; In tetrahydrofuran; methanol; hexane; water;

DOI:10.1055/s-0034-1379502

upstream raw materials:

3-cyclopentylpyridine

2-bromo-pyridine

cyclopentanone

1-(2-bromopyridin-3-yl)cyclopentanol

Refernces

• 1、 -. "Sulfone derivatives as 5-HT7 receptor ligands". Page/Page column 11. . Retrieved 2010/02/09.