N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide

Base Information

• Chemical Name: N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide
• CAS No.: 194996-39-9
• Molecular Formula: C₂₄H₃₉N₃O₇
• Molecular Weight: 481.59
• Mol file: 194996-39-9.mol

Synonyms:N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide

Chemical Property of N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide

There total 4 articles about N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Bis-(2-methoxyethyl)amine (111-95-5) + N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)iminodiacetic acid monoamide (188625-13-0) → N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide (194996-39-9)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

DOI:10.1016/S0968-0896(98)00128-X

Reference yield:

N-((tert-butyloxy)carbonyl)iminodiacetic acid (56074-20-5) → N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide (194996-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: EDCI / dimethylformamide / 1 h / 25 °C

2: dimethylformamide / 25 °C

3: PyBOP; iPr₂NEt / dimethylformamide / 16 h / 25 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00423-5

Reference yield:

N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride (56074-21-6) → N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)-N''-di(2-methoxyethyl)iminodiacetic acid diamide (194996-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 25 °C

2: PyBOP; iPr₂NEt / dimethylformamide / 16 h / 25 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00423-5

upstream raw materials:

Bis-(2-methoxyethyl)amine

N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)iminodiacetic acid monoamide

N-((tert-butyloxy)carbonyl)iminodiacetic acid

N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride

Refernces

• 1、 Boger, Dale L.,Ducray, Pierre,Chai, Wenying,Jiang, Weiqin,Goldberg, Joel. "Higher order iminodiacetic acid libraries for probing protein-protein interactions". . p. 2339 - 2344. Retrieved 2007/10/03.