Oxiranemethanol,3-methyl-3-[(phenylmethoxy)methyl]-,(2R,3R)-rel-(9CI)

Base Information

Chemical Name:Oxiranemethanol,3-methyl-3-[(phenylmethoxy)methyl]-,(2R,3R)-rel-(9CI)
CAS No.:794513-01-2
Molecular Formula:C₁₂H₁₆O₃
Molecular Weight:208.257
Hs Code.:
Mol file:794513-01-2.mol

Synonyms:Oxiranemethanol,3-methyl-3-[(phenylmethoxy)methyl]-, (2R,3R)-rel- (9CI)

Suppliers and Price of Oxiranemethanol,3-methyl-3-[(phenylmethoxy)methyl]-,(2R,3R)-rel-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Oxiranemethanol,3-methyl-3-[(phenylmethoxy)methyl]-,(2R,3R)-rel-(9CI)

Chemical Property:

Boiling Point:323.9±17.0 °C(Predicted)
PKA:14.44±0.10(Predicted)
PSA：41.99000
Density:1.120±0.06 g/cm3(Predicted)
LogP:1.35300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Oxiranemethanol,3-methyl-3-[(phenylmethoxy)methyl]-,(2R,3R)-rel-(9CI)

There total 18 articles about Oxiranemethanol,3-methyl-3-[(phenylmethoxy)methyl]-,(2R,3R)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 62311-52-8
(2E) 1-benzyloxy-2-methyl-2-buten-4-ol

: 332888-38-7,794513-01-2
(2S,3R)-(3-benzyloxymethyl-3-methyl-oxiranyl)-methanol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; (-)-diethyl tartrate; In dichloromethane; at -23 - -20 ℃; for 15h;
DOI:10.1021/jo005732o

Reference yield: 88.0%

: ((2S,3S)-3-Benzyloxymethyl-3-methyl-oxiranylmethoxy)-triisopropyl-silane

: 794513-01-2
((2S,3S)-3-Benzyloxymethyl-3-methyl-oxiranyl)-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/ja0469075

Reference yield:

: 223906-15-8
3-methyl-1-triisopropylsiloxy-2-butene

: 794513-01-2
((2S,3S)-3-Benzyloxymethyl-3-methyl-oxiranyl)-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 35 percent / SeO₂; tBuOOH / CH₂Cl₂; toluene / 48 h

2.1: 75 percent / mCPBA / CH₂Cl₂ / 3 h / 0 °C

3.1: NaH / tetrahydrofuran; dimethylsulfoxide / 0.5 h / 20 °C

3.2: 90 percent / tetrabutylammonium iodide / tetrahydrofuran; dimethylsulfoxide / 60 °C

4.1: 88 percent / tetrabutylammonium fluoride / tetrahydrofuran

With tert.-butylhydroperoxide; selenium(IV) oxide; tetrabutyl ammonium fluoride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja0469075