tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate
CAS No.:1346507-69-4
Molecular Formula:C₄₉H₈₈N₆O₁₉
Molecular Weight:1065.27
Hs Code.:

tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

Synonyms:tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

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Chemical Property of tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

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Technology Process of tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

There total 8 articles about tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1346507-68-3
tert-butyl (2R,3R,6S)-2-((1R,2S,3S,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-nitro-N-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)methyl)tetrahydro-2H-pyran-3-ylcarbamate

: 1346507-69-4
tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol; In acetonitrile; at 20 ℃; for 2.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1346507-69-4
tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl trifluoroacetate, / dimethyl sulfoxide / 1.5 h / 20 °C

1.2: 6 h / 0 - 20 °C

2.1: potassium carbonate / tetrabutylammomium bromide / acetonitrile / 24 h / 60 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol / acetonitrile / 2.5 h / 20 °C

With ethyl trifluoroacetate,; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol; tetrabutylammomium bromide; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 26098-04-4
Gentamicin C1a

: 1346507-69-4
tert-butyl (2R,3R,6S)-2-((1R,2SS,4R,6S)-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(N-methyl-tert-butoxycarbonylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxy-4-((S)-2-hydroxy-3-tert-butoxycarbonylaminopropanamido)-6-tert-butoxycarbonylaminocyclohexyloxy)-6-((2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)methyl)tetrahydro-2H-pyran-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol; dichloromethane / 18 h / -60 - 20 °C

2.1: zinc(II) acetate dihydrate / methanol / 1 h / 20 °C

2.2: 18 h / 20 °C

2.3: 0.5 h

3.1: ethyl trifluoroacetate, / dimethyl sulfoxide / 1.5 h / 20 °C

3.2: 6 h / 0 - 20 °C

4.1: potassium carbonate / tetrabutylammomium bromide / acetonitrile / 24 h / 60 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol / acetonitrile / 2.5 h / 20 °C

With ethyl trifluoroacetate,; zinc(II) acetate dihydrate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 2-hydroxyethanethiol; tetrabutylammomium bromide; In methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;