methyl (2S,4R)-4-hydroxy-1-(1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxylate

Base Information

• Chemical Name: methyl (2S,4R)-4-hydroxy-1-(1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxylate
• CAS No.: 1004790-01-5
• Molecular Formula: C₁₁H₁₄N₂O₄
• Molecular Weight: 238.243
• Mol file: 1004790-01-5.mol

Synonyms:methyl (2S,4R)-4-hydroxy-1-(1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxylate

Chemical Property of methyl (2S,4R)-4-hydroxy-1-(1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of methyl (2S,4R)-4-hydroxy-1-(1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxylate

There total 1 articles about methyl (2S,4R)-4-hydroxy-1-(1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) + pyrrole-2-carboxyl acid (634-97-9) → methyl (2S,4R)-4-hydroxy-1-(1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxylate (1004790-01-5) + (3R,5S)-5-(methoxycarbonyl)-1-(1H-pyrrole-2-carbonyl)pyrrolidin-3-yl 1H-pyrrole-2-carboxylate (1004790-02-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h; Heating;

DOI:10.1021/ol702866m

upstream raw materials:

L-4-hydroxyproline methyl ester hydrochloride

pyrrole-2-carboxyl acid