(S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide

Base Information

Chemical Name:(S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide
CAS No.:1446006-02-5
Molecular Formula:C₂₅H₃₂N₂O₃
Molecular Weight:408.541
Hs Code.:

Synonyms:(S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide

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Chemical Property of (S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide

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Technology Process of (S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide

There total 4 articles about (S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32936-76-8
1-methylcyclobutane carboxylic acid

: 1446008-11-2
(S)-1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethylamine

: 1446006-02-5
(S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide

Guidance literature:: 1-methylcyclobutane carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

(S)-1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 847728-89-6
(S)-tert-butyl (1-(4-bromophenyl)ethyl)carbamate

: 1446006-02-5
(S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate / 1,4-dioxane / 2 h / 120 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 12 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; johnphos; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1220028-44-3
3-(4-ethoxy-phenoxy)-azetidine

: 1446006-02-5
(S)-1-methyl-cyclobutanecarboxylic acid (1-{4-[3-(4-ethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate / 1,4-dioxane / 2 h / 120 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 12 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; johnphos; In 1,4-dioxane; N,N-dimethyl-formamide;