9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione

Base Information

Chemical Name:9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione
CAS No.:372120-41-7
Molecular Formula:C₁₈H₁₅BrFNO₄
Molecular Weight:408.224
Hs Code.:

Synonyms:9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione

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Chemical Property of 9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione

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Technology Process of 9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione

There total 6 articles about 9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 4-(3-bromo-4-fluoro-phenyl)-2,6,6-trimethyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylic acid methyl ester

: 372120-41-7
9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione

Guidance literature:: 4-(3-bromo-4-fluoro-phenyl)-2,6,6-trimethyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylic acid methyl ester; With pyridine; pyridinium hydrobromide perbromide; In chloroform; at 0 ℃; for 0.333333h;

at 130 ℃; for 0.25h;
DOI:10.1021/jm060549u

Reference yield:

: 85428-68-8
(1,1-dimethylprop-2-ynyloxy)acetic acid methyl ester

: 372120-41-7
9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂SO₄ / Hg(OAc)2 / methanol / 1 h / Heating

2.1: KO-t-Bu / 2-methyl-propan-2-ol; diethyl ether / 0.17 h / 0 °C

3.1: ethanol / 16 h / 80 °C

4.1: pyridinium tribromide; pyridine / CHCl₃ / 0.33 h / 0 °C

4.2: 22 percent / 0.25 h / 130 °C

With pyridine; sulfuric acid; potassium tert-butylate; pyridinium hydrobromide perbromide; mercury(II) diacetate; In methanol; diethyl ether; ethanol; chloroform; tert-butyl alcohol;
DOI:10.1021/jm060549u

Reference yield:

: 115-19-5
2-methyl-but-3-yn-2-ol

: 372120-41-7
9-(3-bromo-4-fluorophenyl)-7,7-dimethyl-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 0.58 h

1.2: tetrahydrofuran / 16.5 h / 0 - 20 °C

2.1: H₂SO₄ / Hg(OAc)2 / methanol / 1 h / Heating

3.1: KO-t-Bu / 2-methyl-propan-2-ol; diethyl ether / 0.17 h / 0 °C

4.1: ethanol / 16 h / 80 °C

5.1: pyridinium tribromide; pyridine / CHCl₃ / 0.33 h / 0 °C

5.2: 22 percent / 0.25 h / 130 °C

With pyridine; sulfuric acid; potassium tert-butylate; sodium hydride; pyridinium hydrobromide perbromide; mercury(II) diacetate; In tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform; tert-butyl alcohol;
DOI:10.1021/jm060549u