furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine

Base Information

• Chemical Name: furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine
• CAS No.: 892738-96-4
• Molecular Formula: C₂₁H₁₉N₅O₃S₂
• Molecular Weight: 453.546
• Mol file: 892738-96-4.mol

Synonyms:furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine

Chemical Property of furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine

There total 8 articles about furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

furan-2-ylmethanamine (617-89-0) + 3-(4-isopropylbenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one (1174392-26-7) → furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine (892738-96-4)

Guidance literature:

furan-2-ylmethanamine; 3-(4-isopropylbenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; at 20 ℃; for 0.5h;

DOI:10.1021/jm300491y

Reference yield: 3.0%

→ furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine (892738-96-4)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

3-bromo-2-thiophenecarboxaldehyde (930-96-1) → furan-2-ylmethyl-[3-(4-isopropylbenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl]amine (892738-96-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium azide / dimethyl sulfoxide / 48 h / 65 °C

2.1: sodium chlorite; aminosulfonic acid / water; acetone / 0.5 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

4.1: sodium ethanolate / ethanol / 0.25 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

5.2: 0.5 h / 20 °C

With sodium chlorite; sodium azide; aminosulfonic acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium ethanolate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1021/jm300491y

upstream raw materials:

3-bromo-2-thiophenecarboxaldehyde

(4-isopropylbenzenesulfonyl)-acetonitrile

furan-2-ylmethanamine

3-(4-isopropylbenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one