5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

Base Information

Chemical Name:5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine
CAS No.:1207840-49-0
Molecular Formula:C₂₂H₂₄N₆
Molecular Weight:372.473
Hs Code.:

Synonyms:5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

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Chemical Property of 5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

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Technology Process of 5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

There total 4 articles about 5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1207840-80-9
7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridin-5-yl trifluoromethanesulphonate

: 6429-11-4
2-(1H-pyrazol-4-yl)ethanamine dihydrochloride

: 1207840-49-0
5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 80 ℃; for 2h;

Reference yield:

: 1207840-78-5
7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridin-5-ol

: 1207840-49-0
5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 25 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 2 h / 80 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 185147-08-4
4-fluoro-3-methylbenzonitrile

: 1207840-49-0
5-(2-(4-pyrazolyl)ethylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 60 - 85 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 2.5 h / -80 - -60 °C / Inert atmosphere

2.2: 4.5 h / -60 - 0 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 25 °C / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 2 h / 80 °C

With pyridine; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; dimethyl sulfoxide;