Technology Process of (R)-1-((2R,5R)-5-(phenylethynyl)tetrahydrofuran-2-yl)propan-1-ol
There total 6 articles about (R)-1-((2R,5R)-5-(phenylethynyl)tetrahydrofuran-2-yl)propan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,1'-bis-(diphenylphosphino)ferrocene; boric acid; palladium diacetate;
In
1,4-dioxane;
at 50 ℃;
for 0.5h;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201105720
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 0 °C / Inert atmosphere
2: AD-mix-β; methanesulfonamide / water; tert-butyl alcohol / 0 °C
3: 1,1'-bis-(diphenylphosphino)ferrocene; boric acid; palladium diacetate / 1,4-dioxane / 0.5 h / 50 °C / Inert atmosphere
With
pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; methanesulfonamide; AD-mix-β; boric acid; palladium diacetate;
In
1,4-dioxane; dichloromethane; water; tert-butyl alcohol;
2: Sharpless dihydroxylation;
DOI:10.1002/anie.201105720
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Noyori's catalyst / 20 °C / Inert atmosphere
2: pyridine / dichloromethane / 0 °C / Inert atmosphere
3: AD-mix-β; methanesulfonamide / water; tert-butyl alcohol / 0 °C
4: 1,1'-bis-(diphenylphosphino)ferrocene; boric acid; palladium diacetate / 1,4-dioxane / 0.5 h / 50 °C / Inert atmosphere
With
pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; Noyori's catalyst; methanesulfonamide; AD-mix-β; boric acid; palladium diacetate;
In
1,4-dioxane; dichloromethane; water; tert-butyl alcohol;
1: Noyori reduction / 3: Sharpless dihydroxylation;
DOI:10.1002/anie.201105720
