Technology Process of N-Cbz-trans-3-hydroxy-cis-4-benzyloxy-L-proline benzyl ester
There total 10 articles about N-Cbz-trans-3-hydroxy-cis-4-benzyloxy-L-proline benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate;
In
dichloromethane;
at 20 ℃;
for 48h;
Inert atmosphere;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / methanol; water; toluene / 0 - 22 °C / pH 9 - 10
2.1: sodium hydride / tetrahydrofuran / 0.17 h / Inert atmosphere
2.2: 2 h / 20 °C
2.3: 20 °C / Inert atmosphere
3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
4.1: sodium carbonate / ethanol; water / 0.12 h / Microwave irradiation
5.1: 2,6-di-tert-butyl-4-methyl-phenol; 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux; Inert atmosphere
6.1: boron trifluoride diethyl etherate / dichloromethane / 48 h / 20 °C / Inert atmosphere; Cooling with ice
With
2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; sodium hydride; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / methanol; water; toluene / 0 - 22 °C / pH 9 - 10
2.1: sodium hydride / tetrahydrofuran / 0.17 h / Inert atmosphere
2.2: 2 h / 20 °C
2.3: 20 °C / Inert atmosphere
3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
4.1: sodium carbonate / ethanol; water / 0.12 h / Microwave irradiation
5.1: 2,6-di-tert-butyl-4-methyl-phenol; 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux; Inert atmosphere
6.1: boron trifluoride diethyl etherate / dichloromethane / 48 h / 20 °C / Inert atmosphere; Cooling with ice
With
2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; sodium hydride; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
![(1R,2S,5S)-6-oxa-3-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid dibenzyl ester](/Databaselist/images/loading.webp)
