dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite

Base Information

Chemical Name:dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite
CAS No.:866332-35-6
Molecular Formula:C₃₄H₃₉F₃NO₁₅P
Molecular Weight:789.65
Hs Code.:

Synonyms:dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite

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Technology Process of dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite

There total 5 articles about dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-α-D-galacto-2-nonulopyranosidonate

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 866332-35-6
dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite

Guidance literature:: With 1H-tetrazole; In acetonitrile; at 20 ℃; for 0.25h;
DOI:10.1021/ol0515210

Reference yield:

: methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-α-D-galacto-2-nonulopyranosidonate

: 67746-43-4
dibenzyl N,N-diethylphosphoramidite

: 866332-35-6
dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite

Guidance literature:: With 1H-tetrazole; In acetonitrile; at -40 - 20 ℃;
DOI:10.1021/ol0515210

Reference yield:

: 862851-24-9
methyl (4-methylphenyl 3,5-dideoxy-2-thio-5-trifluoroacetamido-D-glycero-α-D-galacto-non-2-ulopyranosid)onate

: 866332-35-6
dibenzyl [methyl (4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-D-glycero-β-D-galacto-non-2-ulopyranosid)ulonate] phosphite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h / 20 °C

2: N-bromosuccinimide; H₂O / acetone / 0.5 h / 20 °C

3: 1H-tetrazole / acetonitrile / 0.25 h / 20 °C

With pyridine; 1H-tetrazole; N-Bromosuccinimide; water; In acetone; acetonitrile;
DOI:10.1021/ol0515210