Technology Process of dimethyl 2-[2,2-dimethyl-3-(diphenylmethylamino)propyl]malonate
There total 7 articles about dimethyl 2-[2,2-dimethyl-3-(diphenylmethylamino)propyl]malonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
dimethyl 3,3-dimethyl-2-(diphenylmethylideneamino)cyclobutane-1,1-dicarboxylate;
With
sodium cyanoborohydride; acetic acid;
In
methanol;
at 20 ℃;
for 17h;
With
sodium hydroxide;
In
methanol;
DOI:10.1039/c1ob05872j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridinium chlorochromate / dichloromethane / 18 h / 20 °C
2: pyridine; titanium tetrachloride / tetrahydrofuran / 21 h / 20 °C
3: triethylamine / 4 h / 60 °C / Neat (no solvent)
4: potassium tert-butylate / tetrahydrofuran / 3 h / Reflux
5: sodium cyanoborohydride; acetic acid / methanol / 17 h / 20 °C
With
pyridine; potassium tert-butylate; titanium tetrachloride; sodium cyanoborohydride; acetic acid; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane;
2: Knoevenagel condensation / 3: aza-Michael addition;
DOI:10.1039/c1ob05872j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine; titanium tetrachloride / tetrahydrofuran / 21 h / 20 °C
2: triethylamine / 24 h / 60 °C / Neat (no solvent)
3: potassium tert-butylate; sodium iodide / tetrahydrofuran / 2 h / Reflux
4: sodium cyanoborohydride; acetic acid / methanol / 17 h / 20 °C
With
pyridine; potassium tert-butylate; titanium tetrachloride; sodium cyanoborohydride; acetic acid; triethylamine; sodium iodide;
In
tetrahydrofuran; methanol;
1: Knoevenagel condensation / 2: aza-Michael addition;
DOI:10.1039/c1ob05872j