D-Proline, 4-hydroxy-2-(hydroxymethyl)-1-methyl-5-oxo-, methyl ester, (4S)- (9CI)

Base Information

Chemical Name:D-Proline, 4-hydroxy-2-(hydroxymethyl)-1-methyl-5-oxo-, methyl ester, (4S)- (9CI)
CAS No.:793682-88-9
Molecular Formula:C₈H₁₃NO₅
Molecular Weight:203.195
Hs Code.:
Mol file:793682-88-9.mol

Synonyms:D-Proline, 4-hydroxy-2-(hydroxymethyl)-1-methyl-5-oxo-, methyl ester, (4S)- (9CI)

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Chemical Property of D-Proline, 4-hydroxy-2-(hydroxymethyl)-1-methyl-5-oxo-, methyl ester, (4S)- (9CI)

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Technology Process of D-Proline, 4-hydroxy-2-(hydroxymethyl)-1-methyl-5-oxo-, methyl ester, (4S)- (9CI)

There total 5 articles about D-Proline, 4-hydroxy-2-(hydroxymethyl)-1-methyl-5-oxo-, methyl ester, (4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 224797-56-2
(2R,5R)-5-cyano-2-phenyl-3-oxa-1-azabicyclo[3.3.0]octan-8-one

: 793682-88-9
(2S,4S)-4-hydroxy-2-hydroxymethyl-2-methoxycarbonyl-1-methylpyrrolidin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: KHMDS / tetrahydrofuran; toluene / 0.33 h / -78 °C

1.2: 80 percent / MoOPH / tetrahydrofuran; toluene / 2 h / -78 °C

2.1: hydrochloric acid / 72 h / 110 °C

3.1: 36.2 mg / diethyl ether; methanol / 18 h / 20 °C

With hydrogenchloride; potassium hexamethylsilazane; In tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.1021/jo040216+

Reference yield:

: 224797-50-6
(2R,5R)-5-hydroxy-2-phenyl-3-oxa-1-azabicyclo[3.3.0]octan-8-one

: 793682-88-9
(2S,4S)-4-hydroxy-2-hydroxymethyl-2-methoxycarbonyl-1-methylpyrrolidin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 65 percent / SnCl₄ / CH₂Cl₂ / 4 h / -35 °C

2.1: KHMDS / tetrahydrofuran; toluene / 0.33 h / -78 °C

2.2: 80 percent / MoOPH / tetrahydrofuran; toluene / 2 h / -78 °C

3.1: hydrochloric acid / 72 h / 110 °C

4.1: 36.2 mg / diethyl ether; methanol / 18 h / 20 °C

With hydrogenchloride; tin(IV) chloride; potassium hexamethylsilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo040216+

Reference yield:

: 190850-55-6
(3R)-5-tert-butyldimethylsiloxy-3-phenyl-1H-pyrrolo[1,2-c]oxazole

: 793682-88-9
(2S,4S)-4-hydroxy-2-hydroxymethyl-2-methoxycarbonyl-1-methylpyrrolidin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 77 percent / SnCl₄ / CH₂Cl₂ / 1.3 h / -78 °C

2.1: 65 percent / SnCl₄ / CH₂Cl₂ / 4 h / -35 °C

3.1: KHMDS / tetrahydrofuran; toluene / 0.33 h / -78 °C

3.2: 80 percent / MoOPH / tetrahydrofuran; toluene / 2 h / -78 °C

4.1: hydrochloric acid / 72 h / 110 °C

5.1: 36.2 mg / diethyl ether; methanol / 18 h / 20 °C

With hydrogenchloride; tin(IV) chloride; potassium hexamethylsilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo040216+