1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid
CAS No.:1393448-84-4
Molecular Formula:C₂₅H₃₅N₃O₃
Molecular Weight:425.571
Hs Code.:

Synonyms:1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid

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Chemical Property of 1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid

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Technology Process of 1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid

There total 8 articles about 1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1393448-83-3
methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylate

: 1393448-84-4
1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: methyl 1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylate; With sodium hydroxide; In ethanol; at 80 ℃; for 16h;

With hydrogenchloride; In ethanol; water; at 20 ℃; pH=3 - 4;

Reference yield:

: 26831-52-7
2-amino-5-methoxybenzaldehyde

: 1393448-84-4
1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / -78 - 20 °C

2.1: ammonia / ethanol / 5 h / 135 °C / 1551.49 Torr

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 16 h / 80 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C

5.1: boron tribromide / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

5.2: 3 h / 0 - 80 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

7.1: sodium hydroxide / ethanol / 16 h / 80 °C

7.2: 20 °C / pH 3 - 4

With di-isopropyl azodicarboxylate; ammonia; boron tribromide; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 1882-69-5
5-methoxy-2-nitro-benzoic acid

: 1393448-84-4
1-((6-(trans-4-tert-butylcyclohexyloxy)quinazolin-2-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: borane-THF / tetrahydrofuran / 0 °C / Reflux

2.1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C

3.1: hydrogen; sodium acetate; 20% PtO2/C / ethyl acetate / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / -78 - 20 °C

5.1: ammonia / ethanol / 5 h / 135 °C / 1551.49 Torr

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 16 h / 80 °C

7.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C

8.1: boron tribromide / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

8.2: 3 h / 0 - 80 °C

9.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

10.1: sodium hydroxide / ethanol / 16 h / 80 °C

10.2: 20 °C / pH 3 - 4

With dipyridinium dichromate; borane-THF; di-isopropyl azodicarboxylate; 20% PtO2/C; ammonia; hydrogen; sodium acetate; boron tribromide; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;