(3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

Base Information

Chemical Name:(3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride
CAS No.:1446308-19-5
Molecular Formula:C₂₈H₃₃F₂N₂O₃*Cl
Molecular Weight:519.031
Hs Code.:

Synonyms:(3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

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Chemical Property of (3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

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Technology Process of (3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

There total 4 articles about (3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1446308-18-4
(R)-quinuclidin-3-yl 2-(4,4-difluoropiperidin-1-yl)-2-phenylacetate

: 532-27-4,108321-66-0,164322-25-2
1-chloroacetophenone

: 1446308-19-5
(3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

Guidance literature:: In ethyl acetate; at 20 ℃;

Reference yield:

: 1252603-79-4
2-(4,4-difluoropiperidin-1-yl)-2-phenylacetic acid

: 1446308-19-5
(3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 °C

2: ethyl acetate / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 98-80-6
phenylboronic acid

: 1446308-19-5
(3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 °C

3: ethyl acetate / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;