(2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid
CAS No.:1448667-66-0
Molecular Formula:C₂₇H₂₇NO₄
Molecular Weight:429.516
Hs Code.:

Synonyms:(2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

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Chemical Property of (2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

Chemical Property:

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Technology Process of (2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

There total 10 articles about (2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448668-03-8
C₂₈H₂₉NO₄

: 1448667-65-9
(2S,4S)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

: 1448667-66-0
(2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; Overall yield = 68 %; Overall yield = 105 mg;

Reference yield:

: 1448668-05-0
C₂₈H₂₉NO₄

: 1448667-65-9
(2S,4S)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

: 1448667-66-0
(2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; Overall yield = 56 %; Overall yield = 70 mg;

Reference yield:

: 1799811-83-8
1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate

: 1448667-65-9
(2S,4S)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

: 1448667-66-0
(2S,4R)-4-(benzyloxy)-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: L-Selectride / tetrahydrofuran / 1 h / -78 °C

2: hydrogenchloride / methanol / 20 °C

3: potassium carbonate / water; ethyl acetate / 1.5 h / 0 - 20 °C

4: trifluorormethanesulfonic acid / dichloromethane / 20 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; water; L-Selectride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;