cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide

Base Information

Chemical Name:cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide
CAS No.:1050684-85-9
Molecular Formula:C₂₈H₃₄F₃N₇OS
Molecular Weight:573.685
Hs Code.:

Synonyms:cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide

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Chemical Property of cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide

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Technology Process of cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide

There total 4 articles about cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₈N₆O₂

: 236736-24-6
2-(trifluoromethyl)thiobenzenemethanamine

: 1050684-85-9
cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.bmc.2021.116216

Reference yield:

: 582-22-9,17596-79-1,28163-64-6,45789-52-4
(R)-2-phenylpropylamine

: 1050684-85-9
cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / acetonitrile; water / 0 °C / pH 9 - 10

2: sodium hydroxide / acetonitrile; water / 20 °C / pH 9 - Ca_. 10

3: acetonitrile; water / 80 °C

4: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2021.116216

Reference yield:

: 1050684-29-1
4,6-dichloro-N-[(2R)-2-phenylpropyl]-1,3,5-triazin-2-amine

: 1050684-85-9
cis-4-((4-(methylamino)-6-(((R)-2-phenylpropyl)amino)-1,3,5-triazin-2-yl)amino)-N-(2-((trifluoromethyl)thio)benzyl)cyclohexane-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / acetonitrile; water / 20 °C / pH 9 - Ca_. 10

2: acetonitrile; water / 80 °C

3: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2021.116216