(S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide

Base Information

Chemical Name:(S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide
CAS No.:1306764-74-8
Molecular Formula:C₂₅H₃₀N₂O₄
Molecular Weight:422.524
Hs Code.:

Synonyms:(S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide

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Chemical Property of (S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide

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Technology Process of (S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide

There total 1 articles about (S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 2026-48-4,473-75-6
(S)-valinol

: 1306764-68-0
(E)-3-(3,4-dimethoxystyryl)-1-methyl-1H-indole-2-carboxylic acid

: 1306764-74-8
(S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; pH=9 - 10;
DOI:10.1016/j.tetasy.2011.02.020

Reference yield: 89.0%

: 1306764-74-8
(S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide

: 1306764-58-8
(S,E)-2-(3-(3,4-dimethoxystyryl)-1-methyl-1H-indol-2-yl)-4-isopropyl-4,5-dihyrdoxazole

Guidance literature:: With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; for 5h;
DOI:10.1016/j.tetasy.2011.02.020

Reference yield:

: 1306764-74-8
(S,E)-3-(3,4-dimethoxystyryl)-N-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-1H-indole-2-carboxamide

: 1306764-61-3
(S)-2-(3-(3,4-dimethoxyphenethyl)-1-methyl-1H-indol-2-yl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; methanesulfonyl chloride; triethylamine / dichloromethane / 5 h

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / tetrahydrofuran; methanol / 0.5 h / Cooling with ice

With dmap; sodium tetrahydroborate; nickel(II) chloride hexahydrate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetasy.2011.02.020