tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate

Base Information

Chemical Name:tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate
CAS No.:1393126-54-9
Molecular Formula:C₂₉H₃₅F₃N₄O₃
Molecular Weight:544.617
Hs Code.:

Synonyms:tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate

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Chemical Property of tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate

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Technology Process of tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate

There total 5 articles about tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₂F₃N₃O₂

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 1393126-54-9
tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 455-88-9
5-nitro-2-fluorotoluene

: 1393126-54-9
tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 24 h / 85 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 2482.38 Torr

3: decaborane / methanol / 20 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran; methanol / 60 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With decaborane; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1393125-28-4
1-(2-methyl-4-nitrophenyl)-4-(trifluoromethyl)-1H-imidazole

: 1393126-54-9
tert-butyl 3-(4-(1-(3-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)amino)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 2482.38 Torr

2: decaborane / methanol / 20 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran; methanol / 60 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With decaborane; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;