(R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide

Base Information

Chemical Name:(R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide
CAS No.:1356955-73-1
Molecular Formula:C₃₂H₂₉F₂N₅O₂S₂
Molecular Weight:617.743
Hs Code.:

Synonyms:(R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide

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Chemical Property of (R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide

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Technology Process of (R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide

There total 7 articles about (R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1370421-37-6
C₅₁H₄₃F₂N₅O₂S₂

: 1356955-73-1
(R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide

Guidance literature:: C₅₁H₄₃F₂N₅O₂S₂; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With sodium hydrogencarbonate; In ethyl acetate;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 1207741-56-7
7-benzyl-2-(p-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

: 1356955-73-1
(R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; tin(ll) chloride / methanol; water / 0.5 h / Reflux

1.2: pH 9

2.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 17 h / 20 °C / Inert atmosphere

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; triethylsilane; benzotriazol-1-ol; trifluoroacetic acid; tin(ll) chloride; diisopropyl-carbodiimide; In methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: (R)-2-[2-(3,5-difluorophenyl)acetamido]-3-(tritylthio)propanoic acid methyl ester

: 1356955-73-1
(R)-N-[4-(7-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-2-[2-(3,5-difluorophenyl)acetamido]-3-sulfanylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol / 1 h / 20 °C

1.2: pH 2

2.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 17 h / 20 °C / Inert atmosphere

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With triethylsilane; benzotriazol-1-ol; trifluoroacetic acid; sodium hydroxide; diisopropyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.10.051