(1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine

Base Information

Chemical Name:(1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine
CAS No.:1032342-71-4
Molecular Formula:C₂₆H₂₆F₆N₃O₄PS₂
Molecular Weight:653.606
Hs Code.:

Synonyms:(1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine

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Chemical Property of (1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine

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Technology Process of (1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine

There total 1 articles about (1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1032101-70-4
meso-1,1,1,4,4,4-hexafluoro-N²,N³-ditosylbutane-2,3-diamine

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1032342-71-4
(1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine

Guidance literature:: meso-1,1,1,4,4,4-hexafluoro-N²,N³-ditosylbutane-2,3-diamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.5h;

With phosphorus trichloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

(S)-1-phenyl-ethylamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1016/j.jorganchem.2008.02.008

Reference yield: 86.0%

: 1032342-71-4
(1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine

: 36477-75-5
tungsten pentacarbonyl tetrahydrofuran

: pentacarbonyl((1S)-N-(meso-4,5-bis(trifluoromethyl)-1,3-ditosyl-1,3,2-diazaphospholidin-2-yl)-1-phenylethanamine)tungsten

Guidance literature:: In tetrahydrofuran; under Ar; soln. of W complex (excess) in THF added to ligand in THF; stirred at 20°C overnight; solvent removed by rotary evapn.; excess W(CO)5(THF) eliminated at 45°C under high vac.; residue dissolved in CH2Cl2; filtered; filtrate concd.;
DOI:10.1016/j.jorganchem.2008.02.008