2-Chloro-1-(2-hydroxyphenyl)propan-1-one

Base Information

• Chemical Name: 2-Chloro-1-(2-hydroxyphenyl)propan-1-one
• CAS No.: 74316-25-9
• Molecular Formula: C9H9 Cl O2
• Molecular Weight: 184.622
• DSSTox Substance ID: DTXSID20576010
• Mol file: 74316-25-9.mol

Synonyms:74316-25-9;2-Chloro-1-(2-hydroxyphenyl)propan-1-one;DTXSID20576010

Chemical Property of 2-Chloro-1-(2-hydroxyphenyl)propan-1-one

Chemical Property:

• PSA: 37.30000
• LogP: 2.20220
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

95% ^*data from raw suppliers

2-Chloro-2'-hydroxypropiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)C1=CC=CC=C1O)Cl

Technology Process of 2-Chloro-1-(2-hydroxyphenyl)propan-1-one

There total 7 articles about 2-Chloro-1-(2-hydroxyphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-chloro-3-methyl-2,4-chromandione (74307-71-4) → 2-chloro-1-(2-hydroxyphenyl)-1-propanone (74316-25-9)

Guidance literature:

With water; In 1,4-dioxane; for 12h; Ambient temperature;

DOI:10.1021/ja00403a050

Reference yield: 8.7%

1-(2-Hydroxy-phenyl)-propan-1-on (610-99-1) → phenyl propionate (637-27-4,132899-52-6) + 2-chloro-1-(2-hydroxyphenyl)-1-propanone (74316-25-9) + 4-hydroxypropiophenone (70-70-2)

Guidance literature:

iron(III) chloride; at 170 ℃; for 24h; Mechanism; Product distribution;

Reference yield:

Phenyl 2-chloropropanoate (54225-09-1) → 2-chloro-1-(2-hydroxyphenyl)-1-propanone (74316-25-9)

Guidance literature:

With aluminium trichloride; zuletzt bei 110grad;

upstream raw materials:

1-(2-Hydroxy-phenyl)-propan-1-on

3-chloro-3-methyl-2,4-chromandione

Phenyl 2-chloropropanoate

4-hydroxy-3-methyl-2H-chromen-2-one