3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine

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Chemical Name:3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine
CAS No.:148058-41-7
Molecular Formula:C₂₇H₂₀F₃N₅O₂
Molecular Weight:503.483
Hs Code.:

Synonyms:3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine

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Chemical Property of 3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine

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Technology Process of 3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine

There total 9 articles about 3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 168292-84-0
8-benzyl-6-(4-hydroxyphenyl)-2-<4-(3-trifluoromethyl(diazirin-3-yl))benzyl>-3,7-fihydroimidazo<1,2-a>pyrazin-3-one

: 148058-41-7
3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine

Guidance literature:: With oxygen; In dimethyl sulfoxide; for 2.5h; Ambient temperature;

Reference yield: 71.0%

: 148058-40-6
2-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)acetic acid

: 37156-84-6
4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol

: 148058-41-7
3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; for 4h; Ambient temperature;
DOI:10.1246/cl.1993.287

Reference yield:

: 3-trifluoromethyl-3-<4-(2-hydroxyethyl)phenyl>diazirine

: 148058-41-7
3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / aq. NaOCl (pH 8.6), 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy, Aliquat 336 (tricaprylmethylammonium chloride), aq. KBr / CH₂Cl₂ / 0.17 h / 0 °C

2: 71 percent / DCC, pyridine / 4 h / Ambient temperature

With pyridine; sodium hypochlorite; Aliquat 336; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; dicyclohexyl-carbodiimide; potassium bromide; In dichloromethane;
DOI:10.1246/cl.1993.287