(S)-5-bromo-N₂-(1-(5-fluoropyridin-2-yl)ethyl)-N₄-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: (S)-5-bromo-N₂-(1-(5-fluoropyridin-2-yl)ethyl)-N₄-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine
• CAS No.: 1150263-61-8
• Molecular Formula: C₂₃H₂₃BrFN₇O
• Molecular Weight: 512.384

Synonyms:(S)-5-bromo-N₂-(1-(5-fluoropyridin-2-yl)ethyl)-N₄-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine

Chemical Property of (S)-5-bromo-N₂-(1-(5-fluoropyridin-2-yl)ethyl)-N₄-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine

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Technology Process of (S)-5-bromo-N₂-(1-(5-fluoropyridin-2-yl)ethyl)-N₄-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine

There total 1 articles about (S)-5-bromo-N₂-(1-(5-fluoropyridin-2-yl)ethyl)-N₄-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S)-1-(5-fluoropyridin-2-yl)ethanamine dihydrochloride (1955519-79-5) + 5-bromo-2-chloro-N-(3-(3-methoxyphenethyl)-1H-pyrazol-5-yl)pyrimidin-4-amine (1150263-64-1) → (S)-5-bromo-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine (1150263-61-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 175 ℃; for 2h; Microwave irradiation;

Reference yield:

(S)-5-bromo-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(3-(3-methoxyphenethyl)-2H-pyrazol-5-yl)pyrimidine-2,4-diamine (1150263-61-8) → (S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(3-(3-methoxyphenethyl)-1H-pyrazol-5-yl)pyrimidine-2,4-diamine (1150262-90-0)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In ethanol; for 4h; Heating / reflux;

upstream raw materials:

(1S)-1-(5-fluoropyridin-2-yl)ethanamine dihydrochloride

5-bromo-2-chloro-N-(3-(3-methoxyphenethyl)-1H-pyrazol-5-yl)pyrimidin-4-amine

Downstream raw materials:

(S)-N₂-(1-(5-fluoropyridin-2-yl)ethyl)-N₄-(3-(3-methoxyphenethyl)-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

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