Technology Process of bis(2,4,6-triisopropylphenyl)(4'-bromo-3,3',5'5'-tetramethyl-4-biphenyl)phosphine
There total 3 articles about bis(2,4,6-triisopropylphenyl)(4'-bromo-3,3',5'5'-tetramethyl-4-biphenyl)phosphine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4,4'-dibromo-3,3',5,5'-tetramethylbiphenyl;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 15h;
With
copper(l) chloride;
at -78 - -20 ℃;
for 12h;
bis(2,4,6-tri-isopropylphenyl)phosphinous chloride;
In
tetrahydrofuran;
for 24h;
Heating;
DOI:10.1016/j.jorganchem.2004.10.031
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 76 percent / palladium(II) acetate; tetra-n-butylammonium bromide; potassium carbonate / dimethylformamide; H2O; propan-2-ol / 12 h / 115 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 15 h / -78 °C
2.2: copper(I) chloride / 12 h / -78 - -20 °C
2.3: 67 percent / tetrahydrofuran / 24 h / Heating
With
n-butyllithium; tetrabutylammomium bromide; palladium diacetate; potassium carbonate;
In
tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.jorganchem.2004.10.031
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phosphorus trichloride; n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 °C
1.2: phosphorus trichloride / 0.5 h / -78 °C
1.3: 92 percent / 2 h / -78 - -20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 15 h / -78 °C
2.2: copper(I) chloride / 12 h / -78 - -20 °C
2.3: 67 percent / tetrahydrofuran / 24 h / Heating
With
n-butyllithium; phosphorus trichloride;
In
tetrahydrofuran; hexane;
DOI:10.1016/j.jorganchem.2004.10.031