C₂₉H₃₉NO₆Si

Base Information

• Chemical Name: C₂₉H₃₉NO₆Si
• CAS No.: 1265279-45-5
• Molecular Formula: C₂₉H₃₉NO₆Si
• Molecular Weight: 525.717
• Mol file: 1265279-45-5.mol

Synonyms:C₂₉H₃₉NO₆Si

Chemical Property of C₂₉H₃₉NO₆Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₉NO₆Si

There total 18 articles about C₂₉H₃₉NO₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(trimethylsilyl)-ethyl 3-amino-2,4-dihydroxybenzoate (1020070-44-3) + C17H22O3 → C29H39NO6Si (1265279-45-5)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 23 ℃; for 14h; Inert atmosphere;

DOI:10.1002/ejoc.201001281

Reference yield:

C29H34O3Si (1048970-79-1) → C29H39NO6Si (1265279-45-5)

Guidance literature:

Multi-step reaction with 16 steps

1.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: [bis(acetoxy)iodo]benzene; potassium hydrogencarbonate / 0.5 h / 0 - 23 °C / Inert atmosphere

4.1: Trimethyl borate / toluene / 16.3 h / 23 °C / Inert atmosphere; Reflux

5.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / 23 °C

6.1: pyridinium chlorochromate / dichloromethane / 16 h / 23 °C / Inert atmosphere; Molecular sieve

7.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - 0 °C / Inert atmosphere

8.1: bis-triphenylphosphine-palladium(II) chloride; formic acid; tributyl-amine / N,N-dimethyl-formamide / 16 h / 23 - 78 °C / Inert atmosphere

9.1: methanol; samarium diiodide / tetrahydrofuran / 0.33 h / 23 °C / Inert atmosphere

10.1: tetrahydrofuran / 0.5 h / 0 - 23 °C / Inert atmosphere

11.1: tert.-butylhydroperoxide / decane; ethyl acetate / 0.5 h / 23 °C / Inert atmosphere; Molecular sieve

11.2: 16 h / 23 °C / Inert atmosphere

12.1: Martins sulfurane / dichloromethane / 2 h / 23 °C / Inert atmosphere

13.1: N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

13.2: 3 h / -78 - 0 °C / Inert atmosphere

14.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.25 h / 23 °C / Inert atmosphere

14.2: 0.33 h / 23 °C / Inert atmosphere

15.1: methanol; water; lithium hydroxide / 5 h / 23 - 50 °C

16.1: triethylamine; HATU / N,N-dimethyl-formamide / 14 h / 23 °C / Inert atmosphere

With methanol; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; bis-triphenylphosphine-palladium(II) chloride; formic acid; samarium diiodide; Martins sulfurane; Trimethyl borate; tributyl-amine; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; potassium hexamethylsilazane; potassium hydrogencarbonate; triethylamine; HATU; pyridinium chlorochromate; lithium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; decane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 1.1: Corey-Bakshi-Shibata reduction / 4.1: Intramolecular Diels-Alder reaction;

DOI:10.1002/ejoc.201001281

Reference yield:

(2-methoxyphenoxy)-(1,1-dimethylethyl)diphenylsilane (108534-61-8) → C29H39NO6Si (1265279-45-5)

Guidance literature:

Multi-step reaction with 17 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / 0.75 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4.1: [bis(acetoxy)iodo]benzene; potassium hydrogencarbonate / 0.5 h / 0 - 23 °C / Inert atmosphere

5.1: Trimethyl borate / toluene / 16.3 h / 23 °C / Inert atmosphere; Reflux

6.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / 23 °C

7.1: pyridinium chlorochromate / dichloromethane / 16 h / 23 °C / Inert atmosphere; Molecular sieve

8.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - 0 °C / Inert atmosphere

9.1: bis-triphenylphosphine-palladium(II) chloride; formic acid; tributyl-amine / N,N-dimethyl-formamide / 16 h / 23 - 78 °C / Inert atmosphere

10.1: methanol; samarium diiodide / tetrahydrofuran / 0.33 h / 23 °C / Inert atmosphere

11.1: tetrahydrofuran / 0.5 h / 0 - 23 °C / Inert atmosphere

12.1: tert.-butylhydroperoxide / decane; ethyl acetate / 0.5 h / 23 °C / Inert atmosphere; Molecular sieve

12.2: 16 h / 23 °C / Inert atmosphere

13.1: Martins sulfurane / dichloromethane / 2 h / 23 °C / Inert atmosphere

14.1: N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

14.2: 3 h / -78 - 0 °C / Inert atmosphere

15.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.25 h / 23 °C / Inert atmosphere

15.2: 0.33 h / 23 °C / Inert atmosphere

16.1: methanol; water; lithium hydroxide / 5 h / 23 - 50 °C

17.1: triethylamine; HATU / N,N-dimethyl-formamide / 14 h / 23 °C / Inert atmosphere

With methanol; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; bis-triphenylphosphine-palladium(II) chloride; formic acid; samarium diiodide; Martins sulfurane; Trimethyl borate; tributyl-amine; N,N,N,N,-tetramethylethylenediamine; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; sec.-butyllithium; potassium hexamethylsilazane; potassium hydrogencarbonate; triethylamine; HATU; pyridinium chlorochromate; lithium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; diethyl ether; decane; dichloromethane; cyclohexane; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 2.1: Corey-Bakshi-Shibata reduction / 5.1: Intramolecular Diels-Alder reaction;

DOI:10.1002/ejoc.201001281

upstream raw materials:

(1R,6S,8S)-9-methylidenetricyclo[6.2.2.0(1,6)]dodec-2-en-4-one

(1S,5S,6S,8S)-5-methyl-9-methylenetricyclo[6.2.2.0(1,6)]dodec-2-en-4-one

2-(trimethylsilyl)-ethyl 3-amino-2,4-dihydroxybenzoate

C₂₉H₃₆O₃Si

Downstream raw materials:

C₂₄H₂₇NO₆