2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole

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Chemical Name:2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole
CAS No.:1361391-62-9
Molecular Formula:C₂₅H₂₈N₆O₂S
Molecular Weight:476.602
Hs Code.:

Synonyms:2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole

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Chemical Property of 2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole

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Technology Process of 2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole

There total 7 articles about 2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1361391-64-1
4-(3-methyl-1H-1,2,4-triazol-1-yl)phenol

: 1361391-35-6
4-(chloromethyl)-2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl) thiazole

: 1361391-62-9
2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 20h;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1361391-62-9
2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C

2: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

3: water; sodium nitrite; sulfuric acid / 1.5 h / 0 °C / Reflux

4: potassium carbonate / acetonitrile / 20 h / 60 °C

With sulfuric acid; water; hydrogen; potassium carbonate; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 16759-48-1
3-methyl-1-(4-nitrophenyl)-1H-1,2,4-triazole

: 1361391-62-9
2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)methyl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

2: water; sodium nitrite; sulfuric acid / 1.5 h / 0 °C / Reflux

3: potassium carbonate / acetonitrile / 20 h / 60 °C

With sulfuric acid; water; hydrogen; potassium carbonate; sodium nitrite; palladium on activated charcoal; In methanol; acetonitrile;