di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate
CAS No.:648908-84-3
Molecular Formula:C₃₆H₄₄N₆O₈
Molecular Weight:688.781
Hs Code.:

Synonyms:di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

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Chemical Property of di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

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Technology Process of di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

There total 8 articles about di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)(dimethylhydrazono)methyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

: 648908-84-3
di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

Guidance literature:: With phosphate buffer; copper dichloride; In tetrahydrofuran; water; at 0 - 25 ℃; for 7h; pH=7;
DOI:10.1016/S0968-0896(03)00457-7

Reference yield:

: 106918-32-5
4-carbomethoxyphenylacetaldehyde

: 648908-84-3
di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: tetrahydrofuran; H₂O / 20 h / 25 °C

2.1: acetyl chloride / CHCl₃ / 12 h / 25 °C

3.1: 0.250 g / ethanol / 5 h / 60 °C

4.1: 92 percent / Dess-Martin reagent / CH₂Cl₂ / 2 h / 25 °C

5.1: 87 percent / acetic acid / ethanol / 12 h / 25 °C

6.1: NaH / dimethylformamide / 0.25 h / 0 °C

6.2: 39 percent / dimethylformamide / 2 h / 25 °C

7.1: NaH / dimethylformamide / 0.5 h / 0 °C

7.2: dimethylformamide / 2 h / 25 °C

8.1: 0.210 g / sodium methoxide / methanol / 1 h / 25 °C

9.1: LiOH*H₂O / methanol; H₂O / 24 h / 25 °C

10.1: 0.038 g / NaHCO₃; EDCI / dimethylformamide / 24 h / 25 °C

11.1: 64 percent / CuCl₂; phosphate buffer / tetrahydrofuran; H₂O / 7 h / 0 - 25 °C / pH 7

With lithium hydroxide; phosphate buffer; sodium methylate; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; copper dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00457-7

Reference yield:

: 648908-77-4
methyl 4-[2-(1,3-benzoxazol-2-yl)-2-oxoethyl]benzoate

: 648908-84-3
di-tert-butyl N-(4-{1-[(1,3-benzoxazol-2-yl)carbonyl]-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)butyl}benzoyl)-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 87 percent / acetic acid / ethanol / 12 h / 25 °C

2.1: NaH / dimethylformamide / 0.25 h / 0 °C

2.2: 39 percent / dimethylformamide / 2 h / 25 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: dimethylformamide / 2 h / 25 °C

4.1: 0.210 g / sodium methoxide / methanol / 1 h / 25 °C

5.1: LiOH*H₂O / methanol; H₂O / 24 h / 25 °C

6.1: 0.038 g / NaHCO₃; EDCI / dimethylformamide / 24 h / 25 °C

7.1: 64 percent / CuCl₂; phosphate buffer / tetrahydrofuran; H₂O / 7 h / 0 - 25 °C / pH 7

With lithium hydroxide; phosphate buffer; sodium methylate; sodium hydride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper dichloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00457-7