1H-Pyrazole-4-carboxamide,5-amino-1-(2-methylphenyl)-(9CI)

Base Information

• Chemical Name: 1H-Pyrazole-4-carboxamide,5-amino-1-(2-methylphenyl)-(9CI)
• CAS No.: 792953-11-8
• Molecular Formula: C11H12 N4 O
• Molecular Weight: 216.242
• Mol file: 792953-11-8.mol

Synonyms:5-Amino-1-(2-methylphenyl)-1H-pyrazole-4-carboxylicacid amide

Chemical Property of 1H-Pyrazole-4-carboxamide,5-amino-1-(2-methylphenyl)-(9CI)

Chemical Property:

• PSA: 86.93000
• LogP: 2.14330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-4-carboxamide,5-amino-1-(2-methylphenyl)-(9CI)

There total 2 articles about 1H-Pyrazole-4-carboxamide,5-amino-1-(2-methylphenyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(5-amino-1-o-tolyl-1H-pyrazole-4-carbonitrile) (142893-46-7) → (5-amino-1-o-tolyl-1H-pyrazole-4-carboxamide) (792953-11-8)

Guidance literature:

In ice-water;

Reference yield:

→ (5-amino-1-o-tolyl-1H-pyrazole-4-carboxamide) (792953-11-8)

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 0 ℃; for 0.25h;

With dihydrogen peroxide; In water; dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h;

Reference yield: 89.0%

(5-amino-1-o-tolyl-1H-pyrazole-4-carboxamide) (792953-11-8) + ethyl 2-(3-bromophenyl)acetate (14062-30-7) → 6-(3-bromobenzyl)-1-(2-methylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:

(5-amino-1-o-tolyl-1H-pyrazole-4-carboxamide); ethyl 2-(3-bromophenyl)acetate; With sodium methylate; In ethanol; Heating / reflux;

With water; In ethanol; at 20 ℃;

upstream raw materials:

(5-amino-1-o-tolyl-1H-pyrazole-4-carbonitrile)

Downstream raw materials:

rac-1-(2-methylphenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

C₁₆H₁₆N₄O